Publication2021
Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression
The record
- Type
- Publication
- Date
- 18 March 2021
- Level
- International — held abroad
- Journal
- Oncogene
- Volume
- 40
- Issue
- 11
- Pages
- 2002-2017
- Published
- 18 March 2021
- DOI
- 10.1038/s41388-021-01663-2
- Scopus ID
- 85101261572
- ISSN
- 09509232
- Authors
- 13
- Open access
- No
- Citations
- 77
- International co-authorship
- Yes
- Co-author countries
- IN, US
Classification
Every label below carries the reasoning it was assigned on, the confidence band it was assigned in, and what produced it. The rubric is published.
UN Sustainable Development Goals
3.4 Reduce premature mortality from non-communicable diseases and promote mental health and well-being
Study identifies osteopontin as tumor-stroma mediator driving breast cancer progression and identifies OPN-CXCL12 network as potential therapeutic target
- High confidence
- The subject matter is a strong and direct inference from the record type, the funding or organising body, or the programme context, even where the title alone is thin. Example: an ICMR-funded project against SDG 3, on the strength of the agency.
- Judged
- Judged against the published classification rubric, under the rubric and prompt versions recorded with the run that produced it.
- Produced by
- claude-haiku-4-5-20251001, under kortex-publication-v1
9.5 Enhance scientific research, upgrade technological capabilities, and increase researchers and R&D spending
Advances cancer biology research and biomedical innovation through mechanism elucidation of tumor microenvironment interactions
- Moderate confidence
- The alignment is plausible and defensible but rests on an assumption a reasonable reviewer could decline. Published, and surfaced in the review queue for a human to confirm or override.
- Produced by
- claude-haiku-4-5-20251001, under kortex-publication-v1
17.6 Enhance North-South, South-South and triangular cooperation on science, technology and innovation, and knowledge sharing
Structural signal: co-authorship outside India.
- Rule-derived
- Emitted by a deterministic rule from structural signals rather than judged from the record’s text. The rule carries a version, so rule-derived and judged labels stay separable.
- Produced by
- sdg17-structural-v1, under kortex-publication-v1
Viksit Bharat @2047
vb-1.2 Health and well-being
Contributes health advancement through mechanistic insights enabling targeted breast cancer therapeutic development
- Produced by
- claude-haiku-4-5-20251001, under kortex-publication-v1
Each label above carries the instrument and the version that produced it. How each classification is reached.
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Provenance
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- Source rows resolved into this record
- 1
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Citing this record
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KIIT Deemed to be University. “Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression”. Kortex.