Publication2014
Mutations in subunit interface and B-cell Epitopes improve Antileukemic activities of Escherichia Coli asparaginase-II:Evaluation of Immunogenicity in Mice
The record
- Type
- Publication
- Date
- 7 February 2014
- Level
- International — held abroad
- Journal
- Journal of Biological Chemistry
- Volume
- 289
- Issue
- 6
- Pages
- 3555-3570
- Published
- 7 February 2014
- DOI
- 10.1074/jbc.m113.486530
- Scopus ID
- 84893659684
- ISSN
- 00219258
- Authors
- 11
- Open access
- Yes
- Citations
- 36
- International co-authorship
- Yes
- Co-author countries
- DE, IN
Classification
Every label below carries the reasoning it was assigned on, the confidence band it was assigned in, and what produced it. The rubric is published.
UN Sustainable Development Goals
3.4 Reduce premature mortality from non-communicable diseases and promote mental health and well-being
Engineered asparaginase variants (W66Y, Y176F) demonstrate significantly enhanced anti-leukemic activity and reduced immunogenicity against acute lymphoblastic leukemia cells.
- High confidence
- The subject matter is a strong and direct inference from the record type, the funding or organising body, or the programme context, even where the title alone is thin. Example: an ICMR-funded project against SDG 3, on the strength of the agency.
- Judged
- Judged against the published classification rubric, under the rubric and prompt versions recorded with the run that produced it.
- Produced by
- claude-haiku-4-5-20251001, under kortex-publication-v1
9.5 Enhance scientific research, upgrade technological capabilities, and increase researchers and R&D spending
Rational mutagenesis and biotechnology innovation for therapeutic protein development represent advanced research capacity in biomedical engineering.
- Moderate confidence
- The alignment is plausible and defensible but rests on an assumption a reasonable reviewer could decline. Published, and surfaced in the review queue for a human to confirm or override.
- Produced by
- claude-haiku-4-5-20251001, under kortex-publication-v1
17.6 Enhance North-South, South-South and triangular cooperation on science, technology and innovation, and knowledge sharing
Structural signal: co-authorship outside India.
- Rule-derived
- Emitted by a deterministic rule from structural signals rather than judged from the record’s text. The rule carries a version, so rule-derived and judged labels stay separable.
- Produced by
- sdg17-structural-v1, under kortex-publication-v1
Viksit Bharat @2047
vb-1.2 Health and well-being
Leukemia therapeutic development research directly advances cancer treatment capability and health outcomes improvement for affected patient populations.
- Produced by
- claude-haiku-4-5-20251001, under kortex-publication-v1
Each label above carries the instrument and the version that produced it. How each classification is reached.
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Provenance
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- Source rows resolved into this record
- 1
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Citing this record
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KIIT Deemed to be University. “Mutations in subunit interface and B-cell Epitopes improve Antileukemic activities of Escherichia Coli asparaginase-II:Evaluation of Immunogenicity in Mice”. Kortex.